Kuchroo_Pubs_1995-1999

Kuchroo Laboratory
Center for Neurologic Disease Brigham and Women's Hospital Harvard Medical School

Kuchroo Publications 1995-1999

O'Hara RM, Jr. Byrne MC, Kuchroo VK, Nagelin AM, Whitters M, Jayaraman S, Henderson SL, Dorf ME, Collins M. T cell receptor a-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction. J. Immunol.1995; 154:2075-81.

Kuchroo VK, Prabhu Das M, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, and Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the TH1/TH2 developmental pathways: application to autoimmune disease therapy. Cell; 1995, 80:707-18.

Prabhu Das M, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, and Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur. J. Immunol. 1995; 25: 207-11.

Kuchroo VK, Byrne MC, Greenfield E, Whitters M, Nelafsky E, Rao A, Collins M, and Dorf ME. Transfection of TCR a-chains into suppressor and helper cell hybridomas: Production of suppressor factors with predicted antigen specificity. J. Immunol. 1995; 154:5030-38.

Markovic-Plese S, Fukaura H, Zhang J, Al-Sabbagh A, Southwood S, Sette A, Kuchroo VK, and Hafler DA. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J. Immunol. 1995; 155:982-92.

Chen Y, Inobe JI, Marks R, Gonnella P, Kuchroo VK, and Weiner HL. Peripheral deletion of antigen-reactive T cells following oral tolerance. Nature. 1995; 376:177-80.

Nicholson LB, Greer JG, Sobel RA, Lees MB, and Kuchroo, VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity. 1995, 3:397-405.

Greer JM, Sobel RA, Sette A, Southwood S, Lees MB, and Kuchroo, VK. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. J. Immunol. 1996; 156:371-9.

Chen Y, Inobe J-i, Kuchroo VK, Baron J, Janeway CA, and Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc. Natl. Acad. Sci. USA. 1996; 93:388-91.

Prabhu Das M., Cohen A., Zamvil SS, Offner H, and Kuchroo, VK. Prior Exposure to superantigen can inhibit or exacerbate autoimmune encephalomyelitis. T cell repertoire engaged by the autoantigen determines clinical outcome. J. Neuroimmunol. 1996: 71:3-10.

Encinas JA, Lees MB, Sobel RA, Symonowicz C, Greer JA, Shovlin CL, Weiner HL, Seidman C, Seidman JG and Kuchroo VK. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J. Immunol. 1996; 157:2186-92.

Ranger AM, Prabhu Das M., Kuchroo VK, and Glimcher LH. B7-2 (CD86) is essential for the development of IL-4 producing T cells. International Immunology. 1996: 8:1549-60.

Ausubel LJ, Kwan CK, Sette A, Kuchroo VK, and Hafler DA. Complementary mutations in an antigenic peptide allow for cross reactivity of autoreactive T-cell clones. Proc. Natl. Acad. Sci. USA.1996: 93:15317-22.

Nicholson LB, Murtaza A, Hafler B, Sette A, and Kuchroo VK. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc. Natl. Acad. Sci. USA. 1997: 94:9279-84.

Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Hollsberg P, Davis G, Hafler DA, Sharpe A, Freeman GJ, and Kuchroo VK. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: Implications for induction of anti-tumor immunity to T cell tumors. J. Immunol. 1997; 158:2025-34.

Prabhu Das M, Nicholson LB, Greer JM, and Kuchroo VK. Auto-pathogenic Th1 and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. J. Exp. Med. 1997; 186:867-76.

Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997; 159:4799-805.

Waldner H, Sobel RA, Howard E, and Kuchroo VK. Fas and FasL deficient mice are resistant to induction of autoimmune encephalomyelitis. J. Immunol. 1997; 159:3100-3.

Nicholson LB, Waldner H, Carrizosa AM, Sette A, Collins M, and Kuchroo VK. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity. Proc. Natl. Acad. Sci. USA. 1998. 95:264-9.

Bettelli E, Prabhu Das M, Howard ED, Weiner HL, Sobel RA, Kuchroo VK. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10 and IL-4 deficient and transgenic mice. J. Immunol. 1998; 161:3299-306.

Carrizosa AM, Nicholson LB, Farzan M, Southwood S, Sette A, Sobel RA, Kuchroo VK. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J. Immunol. 1998: 161:3307-14.

Encinas J, Wicker L, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CD, Seidman JG, Kuchroo VK. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15cM region containing Il2. Nature Genetics. 1999; .21:158-60.

Stremmel C, Greenfield EA, Howard E, Freeman GJ, Kuchroo VK. B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an IL-4 dependent mechanism. J. Exp. Med. 1999; 189:919-30.

Murtaza A, Kuchroo VK, Freeman GJ. Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands. International Immunology. 1999; 11: 407-16.

Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH. Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of experimental autoimmune encephalomyelitis . J. Exp Med. 1999; 190: 733-40.

Liu L, Kuchroo VK, and Weiner HL. B7.2 and not B7.1 costimulatory molecule is required for the induction of low dose oral tolerance. J Immunology. 1999; 163:2284-90.
Maron R, Hancock WW, Slavin A, Hattori M, Kuchroo V, Weiner HL. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. International Immunology. 1999; 11:1573-80.

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