Kuchroo_Pubs_2000-2004

Kuchroo Publications 2000-2004

Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naïve mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 2000; 191:761-70.

Waldner H, Whitter MJ, Sobel RA, Collins M, Kuchroo VK. Fulminant spontaneous autoimmunity of the central nervous system in myelin proteolipid protein specific T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA. 2000; 97:3412-7.

Nicholson LB, Anderson AC, Kuchroo, VK Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. International Immunology. 2000; 12:205-13.

Anderson AC, Waldner H, Turchin V, Jabs C, Prabhu Das M, Kuchroo VK, Nicholson LB. Autoantigen responsive T cell clones demonstrate unfocused TCR cross-reactivity towards multiple related ligands: implications for autoimmunity. Cell Immunology. 2000; 202:88-96.

Young DA, Lowe LD, Booth SS, Whitters MJ, Nicholson L, Kuchroo VK, Collins M. IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. . J Immunol. 2000; 164:3563-72.

Gaglia JL, Greenfield EA, Mattoo A, Sharpe AH, Freeman GJ, Kuchroo VK. ICAM-1 is critical for activation of CD28-deficient T cells. J. of Immunol. 2000; 165: 6091-8.

McAdam AJ, Chang T, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe A, Freeman GJ. Mouse Inducible Costimulatory Molecule Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells. J Immunol. 2000; 165:5035-40.

Nicholson LB, Kuchroo VK. Selecting killers: the line between life and death. 2000. Nature Immunol. 3:192-4.

Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Identification of genetic loci associated with paralysis, inflammation, and weight loss in murine experimental autoimmune encephalomyelitis. International Immunology. 2001; 3:257-64.

Stremmel C, Exley M, Balk S, Hohenberger W, Kuchroo VK. A unique subset of NK1.1+, CD8a/b+ T cells that are not CD1d and MHC class I restricted, show a natural killer cell activity and lyse multiple tumor targets. Eur J Immol. 2001; 9:2818-28.

Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci. 2001; 21:3740-48.

Theien BE, Vanderlugt CL, Eagar TN, Nickerson-Nutter C, Nazareno R, Kuchroo VK, Miller SD.Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest. 2001; 107:995-1006.

McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001; 2:1109-16.

Monney L, Sabatos C, Gaglia J, Ryu A, Walder H, Chernova T, Manning S, Greenfield EA, Coyle CJ, Sobel RA, Freeman GJ, Kuchroo VK. The Th1 specific cell surface protein, TIM-3, regulates macrophage activation and severity of an autoimmune disease. Nature. 2002; 415:536-41.

Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol. 2002; 168:5070-8.

Jabs C, Chang TT, Sobel RA, Sharpe AH,Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of Autoimmunity. Eur J Immunol. 2002; 32: 2687-97.

Munder M, Bettelli E, Monney L, Slavik JM, Nicholson LB, Kuchroo VK. Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J Exp Med. 2002; 196:1151-62.
Freeman GJ, Sharpe AH, Kuchroo VK. Protect the killer: CTLs need defenses against the tumor. Nat Med. 2002; 787-9.

Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V, Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood. 2002; 100: 2899-907.

Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002; 169:5382-6.

Wahren-Herlenius M, Kuchroo VK. Killer cells to the rescue. Nat Biotechnol. 2002; 20:1205-6.

Gaglia JL, Mattoo A, Greenfield EA, Freeman GJ, Kuchroo VK. Characterization of Endogenous Chinese Hamster Ovary Cell Surface Molecules That Mediate T Cell Costimulation. Cell. Immunol. 2002; 213:83-93.

Kuchroo VK, Nicholson LB. Immunology: Fast and Feel Good? Nature. 2003; 422:27-8.

Bettelli E, Nicholson LB, Kuchroo VK. IL-10, a key effector regulatory cytokine in experimental autoimmune encephalomyelitis. J Autoimmun. 2003; 20:265-7.

Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol. 2003; 170:870-7.

Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003; 5; 197:1073-81.

Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol. 2003; 33:2022-32.

Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003; 21:1033-9.

Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX, Coyle A, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3-ligand regulates Th1 responses and induction of peripheral tolerance. Nat Immunol. 2003; 4:1102-10.

Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutierrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003; 4:1093-101.

Anderson AC, Kuchroo VK. Expression of self-antigen in the thymus: a little goes a long way. J Exp Med. 2003; 198:1627-9.

Khademi M, Illes Z, Gielen A, Marta M, Takasawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. TIM-3 and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J. Immunol. 2004; 172:7169-76.

Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 2004; 20:563-75.

Waldner H, Collins M, Kuchroo VK. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J. Clin. Invest. 2004; 113:990-7.

Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK. The diabetes susceptibility Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J. Immunol. 2004; 173: 157-63.

Greve B, Reddy J, Waldner H, Sobel RA, Kuchroo VK. Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2s congenic mice are relatively resistant to EAE and type-1 diabetes. Eur J Immunol. 2004; 34: 1828-38.

Anderson AC, Reddy J, Nazareno R, Sobel RA, Nicholson LB, Kuchroo VK. Interleukin-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naïve mice. J. Immunol. 2004; 173: 828-834.

Bettelli E, Sullivan B, Szabo, SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT-1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004; 200: 79-87.

Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. PD-L1 Deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. USA. 2004; 101:10691-6.

Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive human autoreactive TCR responses to altered peptide ligands presented by different MHC Class II molecules. J. Immunol. 2004; 173: 1689-98.

Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int. Immunol. 2004; 16:249-56.

Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity. 2004; 20:695-705.

Ellmerich S, Takacs K, Mycko M, Waldner HP, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol. 2004; 34:1839-48.

Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Bäckström BT. Characterization of MHC- and TCR-binding residues of myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol. 2004; 34:165-173.

Petersen TR, Gulland S, Bettelli E, Kuchroo V, Palmer E, Bäckström BT. A chimeric T cell receptor with super-signaling properties. Int. Immunol. 2004; 16:889-894.

Stern JN, Illés Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, Nishimura H, Brosnan CF, Santambrogio L, Kuchroo VK, Strominger JL. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc. Natl. Acad. Sci. USA. 2004; 101:11743-8.

Illés Z, Stern JN, Reddy J, Waldner H, Mycko MP, Brosnan CF, Ellmerich S, Altmann DM, Santambrogio L, Strominger JL, Kuchroo VK. Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc. Natl. Acad. Sci. USA. 2004;101:11749-54.

Tadokoro CE, Vallochi AL, Rios LS, Martins GA, Schlesinger D, Mosca T, Kuchroo VK, Rizzo LV, Abrahamsohn IA. Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi. Autoimmun. 2004; 23:103-15.
Reddy J, Illés Z, Zhang X, Encinas J, Pyrdol J, Nicholson L, Sobel RA, Wucherpfennig KW, Kuchroo VK. Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to EAE. Proc Natl Acad Sci USA. 2004; 101:15434-39.

Kuchroo Laboratory
Center for Neurologic Disease Brigham and Women's Hospital Harvard Medical School